Common Signs Wellbutrin is Working for You

Common Signs Wellbutrin is working for You!

Written by :

Arooj Anjum

Arooj Anjum

Biomedical Engineer
Have you noticed any mood changes and outlook on life since starting Wellbutrin? Wellbutrin has emerged as a ray of hope for millions worldwide in modern psychiatric medicine since 1985. However, spotting the signs Wellbutrin is working is crucial to ensure its effectiveness and to make informed decisions.


15 years of clinical experience has shown that Wellbutrin manages symptoms of depression (MDD or SAD) effectively or helps aid in smoking cessation, like feeling empty, loss of interest in social life, having trouble sleeping, being less concentrated, feeling worthless, and more guilty. Typically, Wellbutrin starts showing its effect within 1-2 weeks. These are the most common signs Wellbutrin is working for you;

  1. Want to socialize
  2. Major positive shift in your mode
  3. You start prioritizing your well-being
  4. Improved sleep routine 
  5. Boost in energy levels
  6. Change in eating habits

If no changes are noticed after two weeks of starting Wellbutrin. Sometimes, your body is taking time to adjust to medication. However, it is recommended to seek the help of a licensed practitioner for further evaluation. Therefore, You need to learn about the signs of Wellbutrin in detail to make an informed decision about your treatment options. This medically reviewed article will serve the purpose.


What Is Wellbutrin?


Wellbutrin, a brand name of Bupropion, is prescribed to treat various mental health conditions majorly, including depression and Seasonal Affective Disorder (SAD). It is also approved as a smoking cessation aid under the brand name Zyban. Doctors also prescribe it for bipolar disorder, sexual dysfunction, and ADHD (attention deficit hyperactivity disorder). However, the  Food and Drug Administration (FDA) hasn’t officially approved these uses.


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How Does Wellbutrin Work


Wellbutrin belongs to the class of Nor-epinephrine-dopamine reuptake inhibitors (NDRIs). Unlike most antidepressants, which work by increasing Serotonin levels in the brain, Wellbutrin primarily works by increasing dopamine and norepinephrine, which play critical roles in improving mood, thus helping with depression.

How Long Does Wellbutrin Take To Work?


All antidepressants, including Wellbutrin, take several weeks to start working and show noticeable changes in mood and feelings. Specifically, it takes about two weeks for Wellbutrin to begin showing its effects, and it may take four weeks or longer to reach its therapeutic stage, where individuals can experience its potential benefits.

Signs Wellbutrin Is Working


As Wellbutrin starts working, noticeable changes begin to show. Early signs Wellbutrin is working are the subtle changes in mood and feelings. Individuals might feel happier, less sad, and more positive toward life. Learn about the common signs of whether Wellbutrin is working if you or your loved one is using it for MDD, Smoking cessation, or ADHD:

a. Wellbutrin For Major Depressive Disorder


Wellbutrin is a highly popular type of antidepressant medication because it can help improve mood, energy levels, and overall health. Unlike other antidepressants, Bupropion doesn’t mess with serotonin reuptake. Instead, it helps by inhibiting the reuptake of norepinephrine and dopamine, two essential mood chemicals. It has less sexual side effects than other antidepressants.


Signs Wellbutrin Is Working For MDD


Signs Wellbutrin Is Working

Signs Wellbutrin Isn’t Working

Positive Changes in Mood No significant improvement in depressive symptoms
Increasing Energy Suicidal behavior
Improved Eating Habits Intolerance
Improved Decision-making Ability Increased anxiety
Fewer Physical Depression Symptoms
Improved Sleep Cycle

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b. Wellbutrin For Smoking Cessation


Bupropion SR is highly efficient in reducing nicotine cravings and withdrawal symptoms, making it easier to quit smoking. However, it is not like a nicotine gum or patch that is used to quit smoking but it is a medication. Therefore, it needs a prescription and should be taken for a shorter period.


Signs Wellbutrin Is Working Signs Wellbutrin Is Not Working
No or Less Desire to Smoke Feeling of Agitation
Better Self Control No Reduction in Nicotine Cravings
Improved Mood Anxiety
Better Eating Habits

c. Wellbutrin For ADHD


Research suggests that Bupropion has better results in treating ADHD than placebo. After taking Wellbutrin for around two to three weeks, patients reported apparent changes.


Signs Wellbutrin Is Working

  • Better focus
  • Reduced impulsivity,
  • Reduced hyperactivity

For this reason, many doctors prescribe Wellbutrin as an off-label treatment for ADHD.


What To Do If Wellbutrin Doesn’t Work?


If Wellbutrin doesn’t seem to be working for the treatment of depression and other conditions, talking to your healthcare provider in this regard is the first and foremost step. Other steps include,

  • Your prescriber might review your dosage to ensure you are taking it in the appropriate doses. Adjusting the dose according to your needs can make a difference in effectiveness.
  • Anti-depressants, including Wellbutrin, take several weeks to produce effects. If you have just started taking it, give it time for the effects to kick in.
  • Your doctor might also suggest combining Wellbutrin with other medications to maximize the effects.
  • Choosing alternative antidepressant medications might also work in your favor.

What Is The Peak Time For Wellbutrin?


When taking Wellbutrin, you must listen to your healthcare practitioner’s advice and follow the instructions because the peak time for Wellbutrin varies from person to person; however, general guidelines say that,

  • Sustained-release tablets of Wellbutrin (Wellbutrin SR) are designed to release the medication into the bloodstream shortly after swallowing, and it takes 3 hours to reach the bloodstream. SR releases medicine for 12 hours, so patients must take it twice daily.
  • For extended release versions of Wellbutrin (Wellbutrin XL) formulated to provide a sustained effect over 24 hours, reaching the bloodline takes approximately 6 hours, reducing the need for frequent dosing.



Side Effects Of Wellbutrin


Some people might tolerate the medication well, but some might suffer from mild to severe side effects. However, it depends on an individual’s health and well-being. People taking Wellbutrin should be aware of the potential serious side effects and rush to the doctor when they encounter any of it. Below are some common side effects that people experience due to Wellbutrin.

  • Headache
  • Nausea or vomiting
  • Dry mouth
  • Insomnia or trouble sleeping
  • Dizziness or lightheadedness
  • Increased sweating
  • Tremors or shaky hands
  • Changes in appetite or weight
  • Stomach issues
  • Anxiety or nervousness
  • Ringing in the ears (tinnitus)
  • Increased heart rate or palpitations
  • Skin rash or itching
  • Poor vision
  • Body aches
  • Sexual side effects, such as decreased libido or erectile dysfunction

Some rare but severe side effects have also been seen in people taking Wellbutrin, like seizures, hallucinations, or risk of suicidal thoughts.

Signs Wellbutrin Is Working: Conclusion


In conclusion, it is instrumental in recognizing the signs that Wellbutrin is working and can help track progress and manage any mental illness effectively. You need to follow up with your healthcare professional to receive personalized guidance. So, any changes in symptoms can be monitored. With proper monitoring and support, Wellbutrin can be a valuable tool in managing depression, quitting smoking, or managing SAD symptoms.

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Medical Disclaimer:


At TherapyFleet, we strive to enhance the quality of life for those dealing with mental health issues. Our licensed medical professionals meticulously research, edit, and review all content before publication. Nonetheless, this information should not replace professional medical advice, diagnosis, or treatment. For medical guidance, please consult your physician or reach out to TherapyFleet’s qualified staff.


Amidst life’s noise, clarity emerges. As Wellbutrin whispers strength, you find a melody in chaos, a rhythm in uncertainty. With each dawn, a glimmer of hope, each step a testament to resilience. In the quiet triumphs, you realize: Wellbutrin is not just a pill, but a beacon guiding you back to yourself.


Frequently Asked Questions:

1. How Does Wellbutrin Alleviate Anxiety?


Wellbutrin, also known as bupropion, is believed to alleviate anxiety through its action on neurotransmitters in the brain, particularly dopamine and norepinephrine. By increasing the levels of these neurotransmitters, it can enhance mood and reduce anxiety symptoms. Additionally, its unique mechanism of action sets it apart from other antidepressants, making it a valuable option for individuals with anxiety disorders. However, as with any medication, it’s essential to consult a licensed healthcare practitioner for personalized advice and adjustments to the dosage of Wellbutrin.

2. What Is Wellbutrin XL Prescribed For?


Wellbutrin XL is commonly prescribed for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD). Additionally, it’s sometimes used to help people quit smoking by managing withdrawal symptoms and reducing nicotine cravings. Its extended-release formulation allows for once-daily dosing, providing a convenient option for those managing depression or SAD. However, it’s important to use Wellbutrin XL only as directed by a healthcare professional and to monitor for any potential side effects.

3. Is Wellbutrin Effective For Weight Loss?


While some individuals may experience weight loss as a side effect of taking Wellbutrin, it is not primarily prescribed for weight loss. Wellbutrin is an antidepressant medication that works by affecting neurotransmitters in the brain, particularly dopamine and norepinephrine. Weight loss may occur due to decreased appetite or increased metabolism in some people, but its effectiveness for weight loss varies among individuals. It’s important to consult with a healthcare provider to determine the most appropriate treatment plan for managing both depression and weight concerns.

4. What Are Common Wellbutrin Side Effects?


Possible side effects of Wellbutrin (bupropion) may include dry mouth, headache, nausea, constipation, and insomnia. Some individuals may also experience agitation, anxiety, tremor, or increased sweating. While these side effects are generally mild and may diminish over time, discussing any concerns with a healthcare professional is essential. In rare cases, Wellbutrin may cause more severe side effects, such as the risk of seizures or any allergic reaction, which can require immediate medical attention.

5. Is Wellbutrin XL or Wellbutrin SR is Better?


Both Wellbutrin XL and Wellbutrin SR are atypical antidepressants that help to treat symptoms of depression and help in smoking withdrawal. The difference is Wellbutrin XL stays longer in your system as it is released slowly in your body, while Wellbutrin SR gets absorbed more quickly, providing a sustained but not as prolonged effect.


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