How Long After Taking Phentermine Can I Take Adderall?

The stimulant effects of the prescription drugs Adderall and Phentermine on the central nervous system (CNS) are comparable. While Adderall is used to treat narcolepsy and Attention Deficit Hyperactivity Disorder (ADHD), Phentermine is mainly prescribed for weight loss. Both medicines have distinct modes of action, and using them together or at close intervals raises questions about possible interactions.

Understanding Phentermine and Adderall

Phentermine and Adderall are usually not recommended together due to similar mechanisms of action. However, due to their off-label uses, sometimes they may be recommended.

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Adderall

Combination of amphetamine salts, Adderall causes the brain to release dopamine and norepinephrine. It is mainly prescribed to treat narcolepsy and ADHD to improve focus, attentiveness, and impulse control. As compared to phentermine, Adderall has greater potential for abuse and dependence because it is a Schedule II controlled substance.

Phentermine

One sympathomimetic amine that suppresses appetite is phentermine. It helps suppress appetite and encourages weight loss by including the brain in releasing norepinephrine. Phentermine is characterized as a Schedule IV controlled substance because of its potential for abuse and it is usually prescribed for brief periods.

How Long After Taking Phentermine Can I Take Adderall?

You should ask your healthcare provider if both medications have been prescribed to you simultaneously. Commonly, you should be waiting at least three to four days after the phentermine dose before taking Adderall. Do not self-medicate on the medications.

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Why Timing Matters: Risks of Taking Phentermine and Adderall Together

Both phentermine and Adderall are Central Nervous System (CNS) stimulants, and their effects can be greatly enhanced when taken at the same time or shortly after one another.

Serious health risks, such as cardiovascular issues, psychological repercussions, and nervous system overstimulation, may result from this.

Cardiovascular Risks

Both medications increase heart rate and blood pressure. Taking them together can:

Increase the risk of arrhythmias (irregular heartbeats).
Lead to palpitations or chest pain.
Exacerbate hypertension (high blood pressure).

Psychological Effects

Phentermine and Adderall can cause feelings of anxiety, restlessness, or irritability. Combining both of them can cause intense effects, causing

Severe anxiety or panic attacks.
Mood swings or agitation.

Overstimulation

When two stimulants are used together, the nervous system may become overloaded, leading to:

insomnia or difficulty unwinding.
Muscle tremors or twitches.
A higher likelihood of stimulant overdose, which may include symptoms like confusion, hallucinations, or seizures.

When Is It Safe to Take Both Medications?

In rare cases, using phentermine and Adderall to treat ADHD in a patient receiving weight loss treatment is medically recommended. However, you should work closely with your professional during this.. The timing depends on several factors, such as the half-life of each medicine, the person’s health, and the doctor’s recommendations.

1. Phentermine Half-life

The half-life of phentermine is around 20 hours, which indicates that the body may take around 20 hours to get rid of half of the medication. In other words, phentermine takes about four to five half-lives, or about 80 to 100 hours, to get completely rid of it.

2. Adderall Half-life

The half-life of Adderall depends on its type of formation

Immediate-Release (IR): 9-11 hours
Extended-Release (XR): 12-14 hours

It may take 2–3 days for Adderall to be fully metabolized and eliminated.

Recommended Waiting Period

Your doctor will determine this. However, the generally it is this:

Wait at least three to four days after taking phentermine before beginning Adderall to avoid risks.
A longer wait period may be advised if the phentermine dosage is high.

You should always speak with your healthcare provider depending on your medical condition.

Key Factors to Consider

Medical History

Some key factors can make the intake of Adderall and phentermine risky if taken right after one another. These key factors include:

Pre-existing heart conditions (e.g. hypertension, arrhythmias)
Anxiety disorder or history of panic attacks.
Thyroid disorders or hyperthyroidism

Dosage Levels

If the dosages of both medications are taken in higher amounts, then their effects and clearance times might take longer. Healthcare providers must be consulted to determine the precise dosages.

Monitoring for Side Effects

Even if sufficient time has passed between doses, be mindful of possible adverse effects. Seek medical help immediately if you face these problems:

Severe chest pain or palpitations.
Dizziness or fainting.
Confusion or hallucinations.

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Interaction Between Phentermine and Adderall

Amplified Sympathomimetic Effects

Phentermine and Adderall both also stimulate the Sympathetic Nervous System (SNS), which has a compounding effect on blood pressure, heart rate, and alertness.

Overload of Dopamine and Norepinephrine

Adderall and phentermine both increase norepinephrine, and Adderall additionally increases dopamine. Excessive levels of these neurotransmitters can cause:

Overstimulation.
Emotional instability.
Neurotoxicity in severe cases.

Be sure to talk to your healthcare provider before switching to any medication or taking it with another.

Medical Disclaimer:

At Therapy Fleet, we strive to enhance the quality of life for those dealing with mental health issues. Our licensed medical professionals meticulously research, edit, and review all content before publication. Nonetheless, this information should not replace professional medical advice, diagnosis, or treatment. For medical guidance, please consult your physician or reach out to Therapy Fleet’s qualified staff.

Taking care of yourself with kindness and daily attention.

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FAQs

1. Is it safe to mix Phentermine and Adderall? Why do doctors advise against it?

No, mixing Phentermine and Adderall can increase the risk of severe side effects like elevated heart rate, high blood pressure, and anxiety. Both are stimulants and combining them may lead to overstimulation or cardiovascular issues.

2. Which medication is stronger phentermine and Adderall?

Adderall is generally stronger in its impact on focus and cognitive function due to its amphetamine composition, while Phentermine primarily targets appetite suppression.

3. Are Adderall and Phentermine similar?

Yes, both are stimulants and affect the central nervous system, but Adderall is primarily for ADHD and narcolepsy, while Phentermine is for weight loss.

4. Does Phentermine Give You Energy?

Yes, Phentermine can boost energy levels due to its stimulant effects on the nervous system.

Sources

Johnson, D. B., & Quick, J. (2023, March 27). Topiramate And Phentermine. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482165/
Johnson, D. B., & Quick, J. (2023, March 27). Topiramate And Phentermine. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482165/
NSW Health. (2021). Schedule 4 appendix D drugs – Prescribed restricted substances. Www.health.nsw.gov.au. https://www.health.nsw.gov.au/pharmaceutical/Pages/sch4d.aspx