How Long Does Lexapro Stay in Your System

How Long Does Lexapro Stay in Your System

Written by :

Picture of Aisha Bibi

Aisha Bibi

Clinical psychologist

Contents

How long does Lexapro stay in your system? Learn about its half-life, withdrawal effects, how to minimize effects, and how to stop Lexapro safely.

How Long Does Lexapro Stay in Your System

If you are considering starting or stopping Lexapro (Escitalopram), you may be wondering: How Long Does Lexapro Stay in Your System?

This is crucial to understand the safe and effective use of Lexapro. It takes nearly 6 or 7 days for most of the medication to be eliminated from your body after a single dose.

You can seek professional guidance and ongoing support from licensed healthcare providers at Therapy Fleet to cope with mental health challenges such as depression, anxiety, Panic disorder, or PTSD. Also, you may consider therapy like PTSD Online TherapyAnxiety Online TherapyEMDR Online TherapyCBD Online Therapy,  etc.

Lexapro

Lexapro is a brand name of Escitalopram, which belongs to a medication class, selective serotonin reuptake inhibitors (SSRI). It is one of the most commonly used antidepressants to treat a certain type of depression and anxiety. Lexapro is a prescription medication and is taken by mouth (oral medication).

It is available in the following dosage forms:

  1. Tablet
  2. Solution

FDA-approved Uses of Lexapro

FDA-approved uses of Lexapro include:

  1. Major depressive disorder
  2. Generalized anxiety disorder

Lexapro is sometimes used off-label, and Off-label uses of Lexapro (Escitalopram) are

  1. Social anxiety disorder
  2. Obsessive-compulsive disorder
  3. Panic disorder
  4. Post-traumatic stress disorder
  5. Premenstrual dysphoric disorder

WARNING!

  • Antidepressants, including Lexapro (Escitalopram), may increase the risk of suicidal thoughts or suicidal behavior in children, adolescents, and young adults.
  • Patients who are taking antidepressants should be closely monitored because depression itself may also lead to suicidal thoughts or suicidal attempts.

If you notice any unusual symptoms or behavior, seek medical attention immediately. You can also contact the FDA to report side effects. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch.

  • Lexapro is not approved for children under 12 years of age
  • SSRIs or SNRIs, including Lexapro, may pose a risk of developing serotonin syndrome. It’s rare but can be life-threatening.
  • SSRIs, including Lexapro, may increase the risk of bleeding. It is not recommended to use blood thinners, NSAIDs, or aspirin, and always consult your healthcare provider before combining medications.

Careful monitoring and caution are advisable.

Half-life of Lexapro 

A drug’s half-life means the time it takes for the concentration of the medication in your bloodstream to be decreased by half (50%). The half-life timeline helps you understand how long Lexapro stays in your system and how long it takes to leave your body. 

Lexapro has a half-life of approximately 27 to 32 hours. This means about half of each dose remains in your system after that time. It takes 5 to 6 half-lives for a drug to be mostly cleared.

Half-lives vary between medications. Understanding this concept also helps explain why some medications require slow, gradual tapering rather than abrupt discontinuation.

 

Ask an Expert!

Q. Can I take lexapro and hydroxyzine together?

 

Hydroxyzine and Lexapro carry a major risk of drug interaction. The combination of Lexapro and Hydroxyzine may increase serious risks, such as irregular heart rhythm and the chance of QT prolongation that can, in rare cases, lead to serious irregular heartbeat.

Do not combine medications without explicit direction from your healthcare provider.  If you are unsure whether this combination is right for you, schedule an online consultation at Therapy Fleet to ensure safe and proper use.

How Long Does Lexapro Stay in Your System

Lexapro typically remains in your system for about 6 to 7 days after your last dose. This timeframe is based on half-life and how the body processes and eliminates it.  

Lexapro Detection may vary, depending on different personal factors such as 

  1. Dosage
  2. Frequency and duration of use
  3. Metabolism
  4. Body composition
  5. Body weight
  6. Liver function

These factors can slow down or speed up how long Lexapro stays in your system.

 Experts suggest that it takes about 5 half-lives for a drug to be mostly cleared from your system, which aligns with the 6 to 7-day elimination timeline for Lexapro.

It is essential to consult with a licensed professional before making any changes to the treatment. Therapy Fleet can guide and provide a personalized treatment plan tailored to your needs.

Why Does It Matter How Long Lexapro Stays in Your System

Understanding how long Lexapro stays in your system is important for several reasons.

1. Planning for Pregnancy

If you are pregnant or planning to become pregnant, knowing how long Lexapro stays in your system helps your healthcare professional determine safe use.

2. Managing Side Effects or Withdrawal Symptoms

The medication does not leave your system immediately after stopping Lexpro. Your healthcare provider determines the timing for dose adjustment.

3. Switching Antidepressants

If you want to switch to another antidepressant, residual Lexapro can affect and increase the risk of drug interaction. A proper tapering period is necessary.

Lexapro Withdrawal and Discontinuation Symptoms

Withdrawal symptoms are unpleasant effects of stopping antidepressants abruptly or reducing them too quickly. Possible withdrawal effects may include:

  1. Nausea
  2. Dry mouth
  3. Vomiting
  4. Diarrhea
  5. Dizziness
  6. Fatigue
  7. Headaches
  8. Mood changes
  9. Irritability
  10. Insomnia
  11. Anxiety

Withdrawal effects may be higher if a medication is used for a prolonged period or stopped suddenly.

It is essential to consult a licensed healthcare provider before starting or stopping antidepressants, including Lexapro.

IMPORTANT

If a person is experiencing any signs of depression during the withdrawal period, it is imperative to seek medical attention immediately.

5 Effective Tips to Minimize Withdrawal Effects

Stopping antidepressants, including Lexapro (escitalopram), Prozac (fluoxetine), Celexa (citalopram), or Zoloft (sertraline), can lead to antidepressant discontinuation syndrome if stopped suddenly. Here are evidence-based tips to minimize withdrawal symptoms:

  1. Taper gradually (gradual dose reduction) under medical supervision
  2. Follow your prescribed tapering schedule
  3. Monitor your symptoms carefully
  4. Don’t skip the prescribed doses
  5. Practice supportive self-care practices such as staying hydrated, maintaining a balanced diet, getting adequate sleep, and managing stress.

If you experience unusual or severe symptoms, seek immediate medical help.

9 Safety Tips When Taking Lexapro (Escitalopram)

Taking Lexapro safely is important for achieving effective results.

  1. Take Lexapro exactly as prescribed by your doctor
  2. Keep your updated prescription with you in case of an emergency
  3. Monitor common side effects of Lexapro, which may include:
  • Nausea
  • Fatigue
  • Sleep disturbances
  • Sexual side effects
  • Headache
  • Tiredness
  1. Do not combine Lexapro with other medications without consulting your healthcare provider
  2.  Limit or avoid alcohol with Lexapro
  3. Do not stop taking Lexapro abruptly
  4. Do not share medication with anyone
  5. Keep all the medications out of reach of the children
  6. Attend regular follow-up appointments

If you have questions or need guidance about Lexapro treatment, consult a licensed healthcare professional at Therapy Fleet.

Conclusion

Understanding how long Lexapro stays in your system is essential for safe and effective treatment. It can help you better manage potential side effects, minimize withdrawal symptoms, and make informed decisions about your mental health care.

If you are considering starting, stopping, or adjusting Lexapro, a licensed healthcare provider at Therapy Fleet offers medication management, regular check-ins, and individualized care to help monitor your progress and support your mental health journey.

Healing takes time, and asking for help is a courageous step forward.

FAQs

1. How long does it take for lexapro to wear off?

Based on Lexapro’s half-life, it may take 5 to 7 days to wear off, but emotional and physical effects can take longer.

It is essential to consult a licensed healthcare provider to adjust or taper medication gradually.

2. Does Lexapro build up in your system?

Yes, Lexapro builds up in your system until it reaches a steady, consistent level in your bloodstream.

3. Can Lexapro cause neck pain?

Yes, neck pain or shoulder pain is reported as a side effect of Lexapro.

4. Does Lexapro make your jaw tense?

Yes, SSRIs, including Lexapro, may cause bruxism (jaw tension or teeth grinding)

MEDICAL DISCLAIMER 

At TherapyFleet, we strive to enhance the quality of life for those dealing with mental health issues. Our licensed medical professionals meticulously research, edit, and review all content before publication. Nonetheless, this information should not replace professional medical advice, diagnosis, or treatment. For medical guidance, please consult your physician or reach out to Therapy Fleet’s qualified staff.

Contents

Prioritize your mental well-being

Consult a healthcare professional online and receive a treatment plan tailored to your needs.