Wellbutrin vs. Zoloft. Key differences, uses, side effects, and learn which antidepressant may suit you best. Always consult a doctor before switching.
Wellbutrin vs. Zoloft — Key Differences and Which One is Right for You
Depression is a common mental health condition. Depression is a struggle that affects a person’s mood, thoughts, and daily life activities. It affects around 280 million people in the World. Two commonly prescribed medicines that are used to treat depression are:
- Wellbutrin
- Zoloft
Wellbutrin is an FDA-approved antidepressant used to treat major depressive disorder. It belongs to the aminoketone class of antidepressants. It helps regulate chemicals in the brain called norepinephrine and dopamine.
Zoloft is an FDA-approved antidepressant used to treat:
- Depression
- Social anxiety disorder (SAD)
- Obsessive-compulsive disorder (OCD)
- Premenstrual dysphoric disorder (PDD)
- Post-traumatic stress disorder (PTSD)
- Panic disorder (PD)
Zoloft helps balance the level of serotonin in the brain, It belongs to a drug class, SSRI (selective serotonin reuptake inhibitors).
Both of these medications are used for Depression, but they work differently. Wellbutrin belongs to the aminoketones, while Zoloft belongs to the SSRIs class of drugs.
It’s not about which medicine is right. What’s important is which medicine is best for you. Only a doctor or healthcare professional can determine that. If you are struggling with depression, you can seek online help at Therapy Fleet.
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Warning!
The use of antidepressants can be helpful, but in some cases, it may also lead to suicidal ideation.
Family members or caregivers should be vigilant and seek medical advice if they notice unusual behaviour or signs of suicidality.
Only your doctor can guide you on the most appropriate treatment plan for your needs and adjust the medication dosage accordingly. When you start taking Bupropion (Wellbutrin) or receive a refill, your doctor or pharmacist will provide a Medication Guide. Read it carefully, or you can access it on the FDA website. |
Wellbutrin
Wellbutrin is the brand name of Bupropion. Bupropion was FDA-approved in 1985. It is used to treat Depression, seasonal affective disorder, and helps to quit smoking.
Off-label Uses
Bupropion is sometimes used by doctors off-label and is not approved by the FDA. Some such uses are:
- Attention-deficit/hyperactivity disorder
- ADHD (attention-deficit/hyperactivity disorder) in children
- Bipolar Depression
- Obesity
- Antidepressant-induced sexual dysfunction
The medication was initially discontinued due to concerns about seizures. Later, Follow-up research was conducted, and the dosage was redefined. Wellbutrin was reintroduced in 1989 with an adjusted dose to minimize seizure risk.
Wellbutrin belongs to the aminoketone class of drugs. Bupropion tablet form (sustained-release or extended-release) is taken by mouth. Wellbutrin in tablet form can be taken three times per day at intervals of six hours.
Wellbutrin boosts dopamine and norepinephrine (brain chemicals responsible for mood and motivation). Most antidepressants usually affect serotonin levels, but wellbutrin has less serotonin activity.
Zoloft
Zoloft is the brand name of Sertraline. Sertraline was FDA-approved in 1991. It is used to treat:
- Major depressive disorder
- Panic disorder
- Post-traumatic stress disorder
- Social anxiety disorder
- Premenstrual dysphoric disorder
- Obsessive Compulsive Disorder
Non-FDA-approved Uses
- Generalized anxiety disorder
- Binge eating disorder
- Bulimia nervosa
- Body dysmorphic disorder
- Premature ejaculation
Zoloft is an antidepressant that belongs to the SSRI group of drugs. Zoloft (Sertraline) increases the level of Serotonin (responsible for regulating mood and emotions) and relieves symptoms of depression.
Wellbutrin vs Zoloft
Wellbutrin and Zoloft are both prescription medications used to treat major depressive disorder (MDD). These medications are in tablet form and are taken by mouth. Differences between Wellbutrin and Zoloft are given below
| Features | Wellbutrin | Zoloft |
| Generic name | Bupropion | Sertraline |
| Uses | Depression, Seasonal Affective Disorder, and smoking cessation (FDA approved as Zyban) | Depression, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety |
| Drug class | Norepinephrine-Dopamine Reuptake Inhibitors (NDRI) | Selective Serotonin Reuptake Inhibitors (SSRIs) |
| Forms | Immediate-release, extended-release, and sustained-release | Oral tablet and oral solution concentrate |
| Taken by | Mouth (orally) | Mouth (orally) |
| Treatment | Treatment may last from months to years (long term) | Treatment may last from months to years (long term) |
| Suitable age | Adolescents and adults | Children, adolescents, and adults |
| FDA-approved for anxiety | May worsen | Highly effective |
| FDA-approved for smoking cessation | Effective (as Zyban) | Not approved by the FDA. |
| Off-label uses | Attention-Deficit Hyperactivity Disorder | Uses are not FDA-approved |
| Physical weight | Loss of weight or no change | May cause weight gain |
| For sleep | Insomnia | Help with sleep |
| Suitable for | Reduced sexual functions, reduced energy level, and quitting smoking. | Obsessive-compulsive disorder, anxiety, and post-traumatic stress disorder |
| Not suitable | Seizure risk, high anxiety | Sexual dysfunction issue, severe fatigue |
| cost | affordable | affordable |
| Insurance covered | covered | covered |
Side Effects of Wellbutrin
Common side effects of using Wellbutrin are:
- Dry mouth
- Nausea
- Loss of appetite
- Constipation
- Insomnia
- Headaches
Some severe side effects may require special attention or emergency care
- Allergic reaction (swelling of face, lips, or throat, Skin rash)
- Redness, peeling, or blisters on the skin
- Breathing difficulty
- Seizures
- Blurry vision
- Psychosis (rare)
- Suicidal ideation
The above list may not include all possible risks. Call your doctor if you feel any of the above side effects.
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Side Effects of Zoloft
Common side effects of using Zoloft are given below:
- Nausea
- Dry mouth
- Diarrhea
- Dizziness
- Headaches
- Restlesness
- Tremor
- Fatigue
- Anxiety
Some serious side effects are given below, which may require medical attention:
- Severe allergic reactions
- Suicidal ideation
- Hyponatremia (low sodium level in the body)
- Serotonin syndrome (rare)
- Seizures
If you face any side effects, report to the doctor immediately.
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Wellbutrin vs Zoloft: Which One is Better?
Wellbutrin and Zoloft are both effective medications used for treating depression. For some people, Wellbutrin might be helpful because it has fewer side effects. Doctors usually prescribe selective serotonin reuptake inhibitors (SSRIs) as first-line treatment for depression because of their safety and effectiveness. Zoloft (Sertraline) belongs to the SSRI class of drugs.
Every individual has different health conditions, so the results may vary because of each person’s medical condition and how their body responds to treatment.
Always consult your doctor before starting the medications and discuss the side effects and benefits of the drugs.
Your doctor will examine you thoroughly and develop a personalized treatment plan, recommending the ideal medication for your health status, age, and medical history.
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Conclusion
Wellbutrin is an NDRI (Norepinephrine dopamine reuptake inhibitor). It increases norepinephrine and dopamine, making it helpful to treat depression, seasonal affective disorder, and smoking cessation.
Zoloft is an SSRI (Serotonin norepinephrine reuptake inhibitor). It boosts serotonin levels, making it helpful to treat depression, obsessive-compulsive disorder, anxiety, and post-traumatic stress disorder.
Both medications’ effectiveness depends on various factors, such as medical history, symptoms, age, weight, and how your body responds. A doctor can assess the medical history, benefits, and side effects to recommend the most suitable choice.
If you are struggling with any of the disorders listed above, consult a medical professional. Therapy Fleet offers personalized mental health support to guide you to the most suitable option.
Medical Disclaimer:
At Therapy Fleet, we strive to enhance the quality of life for those dealing with mental health issues. Our licensed medical professionals meticulously research, edit, and review all content before publication. Nonetheless, this information should not replace professional medical advice, diagnosis, or treatment. For medical guidance, please consult your physician or reach out to Therapy Fleet’s qualified staff.
Choosing the right antidepressant isn’t about finding the ‘best’ one—It’s about finding the one that fits you best.
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FAQs
1. What should I avoid while taking Sertaline?
Avoid driving or operating heavy machinery until you know how it may affect you. It may impair coordination.
Avoid alcohol while taking Sertraline. It may cause interactions.
2. Can I take Wellbutrin in place of Zoloft?
Wellbutrin and Zoloft contain different active ingredients. Both of the medications are used to treat depression, but without doctor supervision, it is not recommended to switch the drug. Your doctor may slowly taper Zoloft. Talk to your healthcare provider if you want to switch the medications.
3. Can Wellbutrin or Zoloft cause weight loss?
Wellbutrin users are less likely to experience weight gain than Zoloft users. Weight gain is more commonly reported with Zoloft. Studies suggested that Bupropion is linked to weight loss on average, while Sertraline may cause weight change or weight gain.
4. Which antidepressant (Wellbutrin or Zoloft) has few side effects?
People who take antidepressants may face sexual side effects. Some people may have sexual side effects while others may not. Wellbutrin has fewer sexual side effects compared to Zoloft.
Sources
- https://www.who.int/news-room/fact-sheets/detail/depression
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/018644s039s040.pdf
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019839s74s86s87_20990s35s44s45lbl.pdf
- https://www.fda.gov/drugs/fdas-labeling-resources-human-prescription-drugs/patient-labeling-resources#medication-guides
- https://www.ncbi.nlm.nih.gov/books/NBK470212/
- https://www.ncbi.nlm.nih.gov/books/NBK554406/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4502586/
- https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/antidepressants/faq-20058104
